AI@HHMI | AI × Science | AI × Imaging
I'm an AI Scientist at HHMI Janelia Research Campus, leading research projects at the intersection of machine learning, microscopy, physics, and cell biology — spanning AI methods for cryo-electron tomography and light microscopy, including image reconstruction, adaptive optics, and agentic AI. I work closely with biologists, tool builders, theorists, and computer scientists across fields.
HHMI feature on the AI+CryoET project of AI@HHMI — developing AI methods to solve challenges in cryo-electron tomography and resolve cellular architecture at molecular scale.
EMBL Symposium: AI and Biology · selected talk
Announcement of the AI@HHMI collaboration with Anthropic to develop specialized AI agents for scientific labs.
AI@HHMI project combining state-of-the-art techniques in cryo-electron tomography with tailored AI methods to reveal cellular architecture and function at molecular scale.
Collaboration with HHMI Investigators Mike Rosen (UTSW), Eric Gouaux (OHSU), and Elizabeth Villa (UCSD), as well as Rosana Collepardo-Guevara (Cambridge, UK). I lead AI method development at Janelia.
Building AI agents that autonomously operate microscopes. Developed on light-sheet microscopes built by the Shroff lab, with C. elegans developmental imaging as the driving use case.
Jointly led with Hari Shroff (Janelia), developed with P. S. Kesavan, in collaboration with Anthropic.
Correcting sample-induced aberrations in fluorescence microscopy through computational wavefront sensing and image reconstruction, spanning 2D and 3D imaging across multiple microscopy modalities.
Collaboration with the Shroff lab (Janelia).
Physics-based forward models of optical systems, enabling accurate PSF estimation, image reconstruction, and optical system design.
I developed a PSF simulation framework for single-molecule localization microscopy and contributed to Chromatix, a differentiable GPU-accelerated wave-optics library.
Nature Methods · 2026
Preprint (arXiv) · 2025
Optica · 2024
Optics Communications · 2024
Full list: Google Scholar · ORCID
Posts I've co-authored on methods and advances in AI and machine learning:
with Kristin Branson
with Michael Innerberger
