AI@HHMI | AI × Science | AI × Imaging
I'm an independent Machine Learning Researcher in the AI@HHMI initiative at HHMI Janelia Research Campus, leading research projects in AI for Science at the intersection of machine learning, microscopy, physics, and cell biology — spanning AI methods for cryo-electron tomography, agentic AI for microscopy, and AI methods for adaptive optics. I work closely with experimentalists and computer scientists across fields.
HHMI feature on the AI+CryoET project of the AI@HHMI initiative — developing AI methods to solve challenges in cryo-electron tomography and resolve cellular architecture at molecular scale.
EMBL Symposium: AI and Biology · selected talk
Announcement of the AI@HHMI collaboration with Anthropic to develop specialized AI agents for scientific labs.
Combining state-of-the-art techniques in cryo-electron tomography with tailored AI methods to reveal cellular architecture and function at molecular scale. Part of the AI@HHMI initiative.
Collaboration with HHMI Investigators Mike Rosen (UTSW), Eric Gouaux (OHSU), and Elizabeth Villa (UCSD), as well as Rosana Collepardo-Guevara (Cambridge). I lead AI method development at Janelia.
Building AI agents that autonomously operate microscopes. Developed on light-sheet microscopes built by the Shroff lab, with C. elegans developmental imaging as the driving use case.
Jointly led with Hari Shroff (Janelia), developed with P. S. Kesavan, in collaboration with Anthropic.
Correcting sample-induced aberrations in fluorescence microscopy through computational wavefront sensing and image reconstruction, spanning 2D and 3D imaging across multiple microscopy modalities.
Collaboration with the Shroff lab (Janelia).
Physics-based forward models of optical systems, enabling accurate PSF fitting, image reconstruction, and optical system design.
I developed a PSF simulation framework for single-molecule localization microscopy and contributed to Chromatix, a differentiable GPU-accelerated wave-optics library.
Preprint (arXiv) · 2025
bioRxiv · 2025
Preprint
Optica · 2024
Optics Communications · 2024
Full list: Google Scholar · ORCID
Posts I've co-authored on methods and advances in AI and machine learning:
with Kristin Branson
with Michael Innerberger
